Low BALF CD4 T cells count is associated with extubation failure and mortality in critically ill covid-19 pneumonia낮은 BALF CD4 T 세포 수는 중환자의 covid-19 폐렴에서 발관 실패 및 사망률과 관련이 있습니다Article Published on 2022-12-012022-09-11 Journal: Annals of Medicine [Category] 바이오마커, 진단, [키워드] affected alveolar alveolar macrophage analysed average BALF BALF CD4 T-cells count baseline Biomarker bivariate analysis Bronchoalveolar lavage fluid caspase caspase-3 cause CD4 CD4 T cell CD4 T-cell Characteristics clinical Clinical characteristics conducted COVID-19 COVID-19 patients COVID-19 pneumonia COVID-19 pneumonia patient COVID-19 pneumonia patients Critically ill critically ill COVID-19 patients Critically ill COVID-19 pneumonia D-dimer D-dimer level eight enrolled extubation failure. groups help IL-17 IL-6 immunopathology IMPROVE Indonesia intubation Invasive mechanical ventilation Laboratory lung Macrophage material Mortality no significant difference no significant differences outcome Patient performed Pneumonia profile Referral reported right lung severe pneumonia severity significant differences significantly survived T-cells Tertiary Tregs understanding was performed were measured [DOI] 10.1080/07853890.2022.2095012 PMC 바로가기 [Article Type] Article
IgG-RBD Response Due to Inactivated SARS-CoV-2 Vaccine: Alteration in D-Dimer and Fibrinogen Concentrations, Association with Comorbidities and Adverse EffectsArticle Published on 2022-11-032022-11-15 Journal: Laboratory medicine [Category] SARS, 진단, [키워드] Adverse alteration appear blood sample both groups changes in Concentration CoronaVac Coronavirus infection COVID-19 COVID-19 infection D-dimer D-dimer level domain Effect effective fibrinogen fibrinogen level first vaccination IgG Immunoglobulin individual infected individual Infection Mask Measures Participants Protective response Safe SARS-CoV-2 second dose second vaccination Side effects significantly higher statistically subject vaccination vaccination. Vaccine was obtained were measured [DOI] 10.1093/labmed/lmac047 PMC 바로가기
Efficacy and safety of nitazoxanide in treating SARS-CoV-2 infection: a systematic review and meta-analysis of blinded, placebo-controlled, randomized clinical trialsArticle Published on 2022-11-012022-11-15 Journal: European Journal of Clinical Pharmacology [Category] SARS, 치료제, [키워드] 95% CI 95% confidence interval addition anti-inflammatory effect antiparasitic antiviral activity blinded clinical benefit continuous variable COVID-19 D-dimer D-dimer level death dichotomous variable Disease progression Effect effect size Efficacy and safety element eligibility enrolled Evidence Frequency ICU admission in vitro individual Inflammation Invasive mechanical ventilation lactate dehydrogenase LDH magnitude Meta-analysis Mild moderate Moderate COVID-19 nitazoxanide no difference Patient patients peer-reviewed performed Placebo placebo-controlled positive positive RT-PCR Primary outcome randomized clinical trial RCT RCTs receiving reducing reduction in reported risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection. secondary outcome serum biomarker SMD standardized mean difference systematic review tested to define treat treated Viral load WBC were used White blood cell with COVID-19 [DOI] 10.1007/s00228-022-03380-5 PMC 바로가기
Comparative study of the usefulness of risk score assessment in the early stages of COVID-19 affected pregnancies: Omicron variant versus previous variantsArticle Published on 2022-11-012022-11-16 Journal: The journal of obstetrics and gynaecology research [Category] SARS, 변종, 치료기술, [키워드] affected age Blood C-reactive protein Comparative Course COVID-19 D-dimer level Delta Deterioration disease disease onset early stage Epidemic evaluate examination findings Frequency group groups less no significant difference not significantly different omicron Omicron variant parameter Patient Platelet Pneumonia Pregnancy pregnant Prognosis risk risk scoring significantly lower two group utility variant Variant of concern. variants was increased worsening [DOI] 10.1111/jog.15387 PMC 바로가기
Extended coagulation profile of children with Long Covid: a prospective studyArticle Published on 2022-11-012022-11-16 Journal: Scientific Reports [Category] SARS, 치료기술, [키워드] activated acute SARS-CoV-2 infection Adults age analyzed Antigen Biomarker case-control study change characterized children Coagulation cofactor Cohort control group controls D-dimer level D-dimers Diagnosis eight endothelial damage endotheliopathy enrolled explained Extended females fibrinogen Follow-up FVIII Infection initial International IQR ISARIC Italy Long majority microbiologically no significant difference normalized pediatric plasma profile profiles proportion Prospective Study Prothrombin time respiratory Sample SARS-COV-2 infection Symptom Symptoms the median the SARS-CoV-2 von Willebrand factor vWF [DOI] 10.1038/s41598-022-23168-y PMC 바로가기
Thrombosis risk assessment in patients with congenital thrombophilia during COVID – 19 infectionResearch article Published on 2022-10-012022-10-05 Journal: Thrombosis research [Category] 변종, 유전자 메커니즘, 진단, [키워드] absence ACAnticoagulants addition adjusted age Anticoagulant Anticoagulants Antithrombin Antithrombotic association ATAntithrombin BMIbody mass index body mass index case-control study changes in clinical picture Comorbidities Comorbidity comparable Computed tomography Confirmed COVID-19 infection contribute Corona Virus Disease COVID COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients COVIDCorona Virus Disease Critical CTComputed Tomography D-dimer D-dimer level Deep venous thrombosis Diagnosis Direct oral anticoagulant disease DOACDirect Oral Anticoagulant DVTDeep Venous Thrombosis dysfunction evaluate Factor V Leiden factor VIII FEUFibrinogen Equivalent Fibrinogen Equivalent FII G20210AProthrombin mutation Final FV LeidenFactor V Leiden FVIII FVIIIFactor VIII genetic defect HBSHeparin Binding Site Heparin Binding Site individual Infection LMWHlow molecular weight heparin low molecular weight heparin Mild Odds ratio OROdds Ratio outcome parameter Patient patient group PCR/RFLPpolymerase chain reaction/restriction fragment length polymorphism PEPulmonary Embolism polymerase chain reaction/restriction fragment length polymorphism Prophylaxis Prothrombin mutation Pulmonary embolism receive Result risk risk of COVID-19 serious complication severe COVID-19 significantly significantly increased symptomatic thrombosis thrombotic thrombotic complication thrombotic event Thrombotic events Treatment Unusual Thrombosis UTUnusual Thrombosis Venous Thromboembolism vitamin K antagonist VKAVitamin K antagonist VTEVenous Thromboembolism was performed [DOI] 10.1016/j.thromres.2022.08.020 [Article Type] Research article
Increased respiratory dead space could associate with coagulation activation and poor outcomes in COVID-19 ARDSResearch article Published on 2022-10-012022-10-05 Journal: Journal of critical care [Category] 바이오마커, [키워드] Activation APACHE II ARDS Coagulation correlated COVID-19 COVID-19 patients Critically ill D-dimer D-dimer level determine discharge discharged enrolled help identify Increased Invasive mechanical ventilation less likelihood material measurement mechanical ventilation outcome outcomes P/F ratio Patient patients with COVID-19 performed Pneumonia primary endpoint Respiratory dead space Respiratory system Result static compliance subgroup of patient supported volumetric Volumetric capnography [DOI] 10.1016/j.jcrc.2022.154095 [Article Type] Research article
Clinical Characteristics and Implications of Bradycardia in COVID-19 Patients Treated with Remdesivir: A Single-Center Retrospective Cohort StudyArticle Published on 2022-09-012022-11-15 Journal: Clinical drug investigation [Category] SARS, 치료제, [키워드] administration age analyzed antiviral drug blockers bradycardia bradycardic cardiac complication cardiac effect cause Characteristics clinical Clinical characteristics Cohort conducted coronavirus disease COVID-19 COVID-19 patient D-dimer level elimination half-life Endotracheal intubation examined excluded Frame Future hyperlipidemia in-hospital mortality inclusion criteria initiated investigated Mortality occur outcomes Patient predictor previous study Remdesivir reported Retrospective study serum Sex significant difference significantly more statistical test treat Treatment undergo [DOI] 10.1007/s40261-022-01187-x PMC 바로가기
Protective Immunity of COVID-19 Vaccination with ChAdOx1 nCoV-19 Following Previous SARS-CoV-2 Infection: A Humoral and Cellular InvestigationArticle Published on 2022-08-302022-11-15 Journal: Viruses [Category] SARS, 진단, [키워드] activated acute respiratory syndrome antibody Antibody Response caused CD4+ naïve Cell cellular Cellular and humoral immunity cellular response ChAdOx1 ChAdOx1 nCoV-19 Cohort COVID-19 COVID-19 group D-dimer level DAV death effective faster humoral Humoral immunity hybrid immunity. IFN-γ IgG immune response Immunity increase in individual individuals induce infected individual interferon-γ investigated investigation Lymphocytes memory memory B cells naïve neutralizing antibody positive correlation SARS-CoV-2 SARS-CoV-2 vaccine secretion significant difference Support triggered vaccinated individual vaccination Vaccine with COVID-19 [DOI] 10.3390/v14091916 PMC 바로가기
Acute delirium as an initial manifestation of COVID-19 patients with acute ischemic stroke: Report on two casesCase report Published on 2022-08-012022-10-05 Journal: Journal of the Formosan Medical Association = Taiw [Category] COVID19(2023년), SARS, 진단, [키워드] Acute delirium acute ischemic stroke acute respiratory syndrome affective AIS Brain Complication coronavirus coronavirus disease COVID-19 COVID-19 patient D-dimer level delirium diagnose Diagnosis diagnostic diffusion disorder elevated Hospitalized hospitalized COVID-19 patient Hypercoagulopathy Infection initial magnetic resonance imaging management manifestation Neurological complication Neuropsychiatric Patient Psychiatric Psychiatric symptom reperfusion report SARS-CoV-2 SARS-COV-2 infection SARSCoV-2 serum stroke Symptom Symptoms therapeutic therapy time-consuming [DOI] 10.1016/j.jfma.2022.01.025 [Article Type] Case report